Ronald Rugumayo shot an 11-under-par 64 at Entebbe Club on Friday to seize the lead at the Pearl of Africa Sunshine Development tour event.
The Ugandan professional surged from fourth place to sit three shots clear of Nigerian Godwin Okoko heading into Saturday's final round.
Okoko, who shared the lead after Thursday's play, carded an 8-under-par 64 for a 131 aggregate to hold second position.
South African Slade Pickering sits on 7-under-par going into the deciding day at the lakeside venue.
A total of 30 golfers made the cut to feature in the final round at Entebbe.
Eswatini's Dlamini Nobulhle is the sole female professional in the field alongside elite amateurs Joseph Cwinyaai and Joseph Akena.
The argument doing the rounds at the clubhouse is whether Rugumayo can hold his nerve and convert the 54-hole lead into a home-soil victory.
How did Ronald Rugumayo take the lead?
Rugumayo fired an 11-under-par 64 on Friday to move three shots clear at the top of the leaderboard.
- Leader: Ronald Rugumayo (Uganda)
- Second: Godwin Okoko (Nigeria) -3 shots
- Third: Slade Pickering (South Africa)
- Cut: 30 players
- Venue: Entebbe Club
- Final round: Saturday
Source: The Independent Uganda
